Combretum leprosum Mart.: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry and Conservation Needs

Combretum leprosum is a plant species with wide distribution in Brazil known as “mofumbo”, standing out studies associated its pharmacological and ethnobotanical activity. The medicinal applications of the are widely reported literature, using bark, leaves flowers healing agents. Given economic, ecological importance, this work aimed to present systematic review production, conservation status knowledge about different fields knowledge. literature was based on seven categories, characterized according study area: biological and/or activity (32 articles), importance (29), botanical aspects (18), phytochemistry (9), geographic (8), foraging (5) uses (2). Most works address species, application focused antitumor action, treatment against Chagas disease, antinociceptive behavior, antibacterial, antioxidant, anti-inflammatory antiproliferative action. Among compounds isolated from C. applications, 3β-6β-16β-trihydroxylup-20(29)-ene stands out, lupane triterpene parts plant, therapeutic applications. highlighted environmental regeneration, being resistant phytophysiognomies showing tolerance environments contaminated by heavy metals, able represent an important reforestation programs recovery degraded environments. However, even growing number recent years, does not have assessment regarding degree threat, demonstrating need for research possible impacts that representatives may suffer, helping sustainable development programs.